Before you can edit a gene, you need to read it. The most important "free download" for any researcher is the genome of the organism they are studying.

While the software is a free download, the intellectual property regarding commercial use of CRISPR is highly contested. If you plan to sell a product created with these tools, you’ll likely need a license. Summary Checklist for your "CRISPR Download": Benchling (for design) SnapGene Viewer (for visualization) Human Genome Data from NCBI (the target) CHOPCHOP (for precision)

The gold standard. You can download the entire human genome or specific viral sequences (like SARS-CoV-2) for free. 2. The Design Tools: Guide RNA (gRNA) Software

If you are just looking to learn how the process works without a lab:

The phrase "CRISPR free download" is a bit of a trick question in the biotech world. You can’t exactly download a "molecular pair of scissors" to your hard drive, but you download the blueprints, the software, and the genomic data required to use them .

An older but entirely free, cross-platform software for sub-cloning and DNA analysis. 4. The Physical Blueprints: Addgene

CRISPR-Cas9 needs a "map" to find the right spot in the DNA. This map is the gRNA. Designing it manually is nearly impossible, so scientists use free software to do it.

A very popular, lightweight web tool (and downloadable script) that helps you pick the most efficient and least "messy" (low off-target effects) gRNAs.