For the most straightforward experience, there is a dedicated EPANET application available on the Apple App Store .

Users with modern Apple Silicon hardware who want a "one-click" installation without technical configuration. 2. Using Wineskin (Compatibility Layer)

EPANET is a widely used, open-source hydraulic and water quality modeling software developed by the U.S. EPA. While the official version is built specifically for Windows, Mac users can still download and run it through several reliable methods, ranging from compatibility layers like Wine to native third-party builds. 1. The Native App Store Version

Requires macOS 11.0 or later and a Mac with an Apple M1 chip or later .

If you prefer to run the official Windows .exe from the U.S. EPA website , you can use a "wrapper" to make it run on macOS.