Use the "Substances" or "Tranches" menu to define your criteria (e.g., Lead-like, Fragment-like, or FDA-approved).
The ZINC database (Zinc Is Not Commercial) is a massive, free resource used by researchers worldwide for virtual screening and drug discovery. Whether you are looking for a handful of analogs or millions of lead-like molecules, navigating its download options is key. how to download compounds from zinc database
ZINC20 is stable and widely used, while ZINC22 contains significantly more "make-on-demand" compounds (over 30 billion). Use the "Substances" or "Tranches" menu to define