Explain how the amount of ACh released normally exceeds what is needed, ensuring reliable contraction.
The influx of calcium triggers vesicles to fuse with the presynaptic membrane (exocytosis), releasing ACh into the synaptic cleft.
If the EPP is strong enough, it triggers a muscle action potential that travels through T-tubules, releasing calcium from the sarcoplasmic reticulum and causing the muscle to contract. 3. Clinical Significance & Pathophysiology neuromuscular junction ppt free download
Antibodies target the presynaptic calcium channels , reducing the amount of ACh released.
Inhibits Acetylcholinesterase , leading to an overaccumulation of ACh and persistent, uncontrollable muscle spasms. 4. Key Features for your PPT Explain how the amount of ACh released normally
The distal end of a motor neuron axon, packed with synaptic vesicles containing the neurotransmitter Acetylcholine (ACh) .
The conversion of an electrical nerve impulse into a mechanical muscle contraction happens in several rapid steps: causing flaccid paralysis.
A toxin produced by Clostridium botulinum that prevents the release of ACh vesicles, causing flaccid paralysis.