For specific research needs, other platforms offer integrated sequence extraction: File Download Services - RCSB PDB
For multiple structures, the FASTA Download Tool allows you to enter a list of PDB IDs (separated by commas) and choose whether to receive them as a single combined file or individual files.
Download. Uncompressed. /fasta/entry/4HHB/download. FASTA sequence per polymer entity (identified by _ ) Download. Uncompressed. / www.rcsb.org RCSB PDB Newsletter
For researchers needing the entire archive, the PDB maintains a comprehensive file named pdb_seqres.txt.gz on their FTP servers, which contains sequences for every experimental structure currently released. Comparison of Download Options Technical Requirement Format Options Structure Summary Page Individual proteins None (Web browser) Single FASTA file Batch Tool 2–1,000 entries PDB IDs list Combined or individual REST API Automated pipelines Basic scripting (Python/cURL) Direct stream FTP Server Big data/Machine learning High storage & bandwidth Full archive Alternative Specialized Tools
On any Structure Summary page , click the Download Files dropdown and select FASTA Sequence to save the sequence for all chains in that entry.
Use RESTful API endpoints to fetch sequences directly into your scripts. For example, the URL structure https://rcsb.org{PDB_ID} can be used with tools like wget or curl .
Depending on your project scale, you can choose from these primary retrieval methods:
