For large-scale analysis or local BLAST database creation, downloading the complete file via FTP is recommended. Via FTP (Recommended for Full Downloads) Downloads | UniProt help

The file contains all protein sequences from UniProtKB/Swiss-Prot , the manually annotated and reviewed section of the UniProt Knowledgebase.

: Every entry is reviewed by expert curators using experimental data and literature.

: It provides a curated set of sequences, making it smaller and more reliable for many bioinformatics pipelines than the unreviewed TrEMBL database. 2. How to Download the Complete Dataset