Vcp | Better

: VCP extracts misfolded or damaged proteins and directs them to the Ubiquitin-Proteasome System (UPS) or autophagy pathways for degradation.

: It is crucial for the health of mitochondria and the endoplasmic reticulum (ER). Medical Implications and Diseases : VCP extracts misfolded or damaged proteins and

: It facilitates the clearance of proteins from chromatin, a process necessary for various DNA repair mechanisms . In the realm of biology and medicine, —also

In the realm of biology and medicine, —also known as p97 —is a member of the AAA+ (ATPases Associated with diverse cellular Activities) family. It is one of the most abundant proteins in the cell, accounting for roughly 1% of total cytoplasmic content, and is essential for maintaining cellular homeostasis. Core Functions These rare autosomal dominant diseases can manifest as:

When VCP malfunctions due to genetic mutations, it leads to a group of conditions known as . These rare autosomal dominant diseases can manifest as: Springer Nature Link

VCP acts as a molecular "chaperone-like" machine that uses energy from ATP to unfold and extract proteins from complexes or membranes. Its primary roles include: